Oxidizing composition and uses for dyeing, for permanently setting or bleaching keratin fibres

ABSTRACT

The present application relates to a cosmetic composition intended for treating keratin fibers, comprising, in a support which is suitable for keratin fibres: 
     (a) at least one enzyme of 2-electron oxidoreductase type in the presence of at least one donor for the said enzyme; 
     (b) at least one nonionic guar gum; 
     as well as to processes for treating keratin fibers, in particular processes for dyeing, permanently reshaping or bleaching the hair, using this composition.

The present invention relates to an oxidizing composition intended fortreating keratin fibres, comprising at least one enzyme of 2-electronoxidoreductase type in the presence of at least one donor for the saidenzyme and at least one nonionic guar gum, as well as to its uses fordyeing, for permanently reshaping or for bleaching keratin fibres, inparticular human hair.

It is known to dye keratin fibres, and in particular human hair, withdye compositions containing oxidation dye precursors, in particularpara-phenylenediamines, ortho- or para-aminophenols and heterocyclicbases which are generally referred to as oxidation bases. Oxidation dyeprecursors, or oxidation bases, are colourless or weakly colouredcompounds which, when combined with oxidizing products, can give rise tocoloured compounds and dyes by a process of oxidative condensation.

It is also known that the shades obtained with these oxidation bases canbe varied by combining them with couplers or colour modifiers, thelatter being chosen in particular from aromatic meta-diamines,meta-aminophenols, meta-diphenols and certain heterocyclic compounds.

The variety of compounds used as regards the oxidation bases and thecouplers allows a wide range of colours to be obtained.

The so-called “permanent” coloration obtained by means of theseoxidation dyes must moreover satisfy a certain number of requirements.Thus it must have no toxicological drawbacks, it must be able to giveshades of the desired intensity and it must be able to withstandexternal agents (light, bad weather, washing, permanent-waving,perspiration, rubbing).

The dyes must also be able to cover white hair and, lastly, they must beas unselective as possible, i.e. they must give the smallest possiblecolour differences along the same length of keratin fibre, which may infact be differently sensitized (i.e. damaged) between its tip and itsroot.

The oxidation dyeing of keratin fibres is generally carried out inalkaline medium, in the presence of hydrogen peroxide. However, the useof alkaline media in the presence of hydrogen peroxide has the drawbackof causing appreciable degradation of the fibres, as well asconsiderable bleaching of the keratin fibres, which is not alwaysdesirable.

The oxidation dyeing of keratin fibres can also be carried out usingoxidizing systems other than hydrogen peroxide, such as enzymaticsystems. Thus, it has already been proposed to dye keratin fibres, inparticular in patent application EP-A-0,310,675, with compositionscomprising an oxidation dye precursor in combination with enzymes suchas pyranose oxidase, glucose oxidase or uricase, in the presence of adonor for the said enzymes. Although being used under conditions whichdo not result in degradation of the keratin fibres which is comparableto that caused by the dyes used in the presence of hydrogen peroxide,these dye formulations nevertheless lead to colorations which are stillinsufficient, both as regards the homogeneity of the colour distributedalong the fibre (“unison”) and as regards the chromaticity (luminosity),the dyeing power and the resistance to the various aggressive factors towhich the hair may be subjected.

It is known that the most common technique for obtaining a permanentreshaping of the hair consists, in a first stage, in opening the keratin—S—S-disulphide (cysteine) bonds using a composition containing asuitable reducing agent (reduction step) followed, after having rinsedthe head of hair thus treated, by reconstituting, in a second stage, thesaid disulphide bonds by applying to the hair, which has been placedunder tension beforehand (rollers and the like), an oxidizingcomposition (oxidation step, also known as the fixing step) so asfinally to give to the hair the desired shape. This technique thus makesit equally possible either to make the hair wavy or to straighten it orto remove its curliness. The new shape given to the hair by a chemicaltreatment such as above is remarkably long-lasting and in particularresists the action of washing with water or shampoos, as opposed tosimple standard techniques for temporary reshaping, such as hairsetting.

The reducing compositions which may be used in order to carry out thefirst step of a permanent-waving operation generally contain, asreducing agents, sulphites, bisulphites, alkylphosphines or, preferably,thiols. Among the thiols, those commonly used are cysteine and thevarious derivatives thereof, cysteamine and the derivatives thereof,thiolactic acid or thioglycolic acid, the salts thereof and the estersthereof, in particular glyceryl thioglycolate.

As regards the oxidizing compositions needed to carry out the fixingstep, use is usually made in practice of compositions based on aqueoushydrogen peroxide, sodium bromate or persalts such as sodium perborate,which have the drawback of being liable to damage the hair.

The problem of the technique of the permanent-waving operations known todate is that their application to the hair induces long-term adversechanges in the quality of the hair. The essential causes of theseadverse changes in the quality of the hair are a reduction in itscosmetic properties, such as its sheen and its feel, and degradation ofits mechanical properties, more particularly degradation of itsmechanical strength due to swelling of the keratin fibres during therinsing between the reduction step and the oxidation step, which canalso be reflected by an increase in its porosity. The hair is weakenedand can become brittle during subsequent treatments such as blow-drying.

The same problem of adverse changes in keratin fibres is encounteredduring processes for bleaching the hair.

It is known that the permanent reshaping or bleaching of keratin fibrescan also be carried out under milder conditions using oxidizing systemsother than hydrogen peroxide, such as enzymatic systems. Thus, processesfor the permanent reshaping or bleaching of keratin fibres have alreadybeen proposed, in particular in patent application EP-A-0,310,675, withcompositions comprising an enzyme such as pyranose oxidase, glucoseoxidase or uricase, in the presence of a donor for the said enzyme.Although being used under conditions which do not result in degradationof the keratin fibres which is comparable to that caused by conventionalpermanent-waving or bleaching processes, these oxidizing formulationsnevertheless lead to results which are still insufficient, as regardsthe curl hold over time, as regards the compatibility of permanent-wavedor bleached hair with subsequent treatments, as regards the reduction ofthe mechanical properties of the permanent-waved hair, in particular thereduction of the porosity of the hair, and as regards the reduction ofthe cosmetic properties such as the feel, or alternatively as regardsthe uniformity of the bleaching along the keratin fibres.

The aim of the present invention is to solve the problems mentionedabove.

The Applicant has discovered, surprisingly, novel compositionscontaining, as oxidizing system, at least one enzyme of 2-electronoxidoreductase type in the presence of at least one donor for the saidenzyme and at least one nonionic guar gum, which can constitute, in thepresence of oxidation dye precursors (oxidation bases) and optionallycouplers, ready-to-use dye formulations which lead to more homogeneous,more intense and more chromatic colorations without giving rise to anysignificant degradation, these colorations being relatively unselectiveand showing good resistance to the various aggressive factors to whichthe hair may be subjected.

The Applicant has also discovered, unexpectedly, that the use, in aprocess for the permanent reshaping of keratin fibres, of an oxidizingcomposition containing, as oxidizing system, at least one enzyme of2-electron oxidoreductase typein the presence of at least one donor forthe said enzyme and at least one nonionic guar gum, makes it possible tosolve the technical problems mentioned above. In particular, this typeof oxidizing composition improves the curl hold obtained over time,substantially reduces the porosity of permanent-waved hair and improvesthe compatibility of permanent-waved hair with respect to subsequenttreatments.

The Applicant has also discovered, surprisingly, that the use, in aprocess for bleaching keratin fibres, of an oxidizing compositioncontaining, as oxidizing system, at least one enzyme of 2-electronoxidoreductase typein the presence of at least one donor for the saidenzyme and at least one nonionic guar gum makes it possible to solve thetechnical problems mentioned above, in particular to improve thecompatibility of bleached hair with respect to subsequent treatments.This type of oxidizing composition gives a more uniform bleaching effecton the hair and improves the cosmetic properties, such as the feel.

These discoveries form the basis of the present invention.

The subject of the present invention is thus, firstly, a cosmetic and/ordermatological composition intended for treating keratin fibres, inparticular human keratin fibres and more particularly human hair,comprising, in a support which is suitable for keratin fibres:

(a) at least one enzyme of 2-electron oxidoreductase type in thepresence of at least one donor for the said enzyme,

(b) at least one nonionic guar gum.

The 2-electron oxidoreductase(s) used in the oxidizing compositions inaccordance with the invention can be chosen in particular from pyranoseoxidases, glucose oxidases, glycerol oxidases, lactate oxidases,pyruvate oxidases and uricases.

According to the invention, the 2-electron oxidoreductase is preferablychosen from uricases of animal, microbiological or biotechnologicalorigin.

By way of example, mention may be made of uricase extracted from boarliver, urlcase from Arthrobacter globiformis, as well as uricase fromAspergillus flavus.

The 2-electron oxidoreductase(s) can be used in pure crystalline form orin a form diluted in a diluent which is inert with respect to the said2-electron oxidoreductase.

The 2-electron oxidoreductase(s) in accordance with the inventionpreferably represent(s) from 0.01 to 20% by weight approximatelyrelative to the total weight of the composition, and even morepreferably from 0.1 to 5% by weight approximately relative to thisweight.

According to the invention, the term donor is understood to refer to thevarious substrates also necessary for the functioning of the said2-electron oxidoreductase(s).

The nature of the donor (or substrate) for the said enzyme variesdepending on the nature of the 2-electron oxidoreductase used. Forexample, as donors for the pyranose oxidases, mention may be made ofD-glucose, L-sorbose and D-xylose; as a donor for the glucose oxidases,mention may be made of D-glucose; as donors for the glycerol oxidases,mention may be made of glycerol and dihydroxyacetone; as donors for thelactate oxidases, mention may be made of lactic acid and its salts; asdonors for the pyruvate oxidases, mention may be made of pyruvic acidand its salts; and lastly, as donors for the uricases, mention may bemade of uric acid and its salts.

The donor(s) (or substrate(s)) used in accordance with the inventionpreferably represent from 0.01 to 20% by weight approximately relativeto the total weight of the composition in accordance with the invention,and even more preferably from 0.1 to 5% approximately relative to thisweight.

According to the invention, unmodified or chemically modified nonionicguar gums can be used.

The unmodified nonionic guar gums are, for example, the products soldunder the name Vidogum GH 175 by the company Unipectine and under thename Jaguar C by the company Meyhall.

The nonionic guar gums which can be used according to the invention arepreferably modified with C₁-C₆ hydroxyalkyl groups.

Among the hydroxyalkyl groups, mention may be made, for example, ofhydroxymethyl, hydroxyethyl, hydroxypropyl and hydroxybutyl groups.

These guar gums are well known in the state of the art and can beprepared, for example, by reacting corresponding alkene oxides, such as,for example, propylene oxides, with the guar gum, so as to obtain a guargum modified with hydroxypropyl groups.

The degree of hydroxyalkylation, which corresponds to the number ofalkylene oxide molecules consumed by the number of free hydroxylfunctions present on the guar gum, preferably ranges from 0.4 to 1.2.

Such nonionic guar gums optionally modified with hydroxyalkyl groups aresold, for example, under the trade names Jaguar HP8, Jaguar HP60 andJaguar HP120, Jaguar DC 293 and Jaguar HP 105 by the companyRhône-Poulenc (Meyhall) or under the name Galactasol 4H4FD2 by thecompany Aqualon.

The concentration of nonionic guar gum can range from 0.01 to 10% byweight approximately relative to the total weight of the composition,and preferably between 0.1 and 5% approximately.

A subject of the present invention is also a ready-to-use compositionfor the oxidation dyeing of keratin fibres, and in particular humankeratin fibres such as the hair, of the type comprising, in a mediumwhich is suitable for dyeing, at least one oxidation base and, whereappropriate, one or more couplers, which is characterized in that itcontains:

(a) at least one enzyme of 2-electron oxidoreductase type in thepresence of at least one donor for the said enzyme,

(b) at least one nonionic guar gum.

The nature of the oxidation base(s) used in the ready-to-use dyecomposition is not a critical factor. They can be chosen, in particular,from para-phenylenediamines, double bases, para-aminophenols,ortho-aminophenols and heterocyclic oxidation bases.

Among the para-phenylenediamines which can be used as oxidation bases inthe dye compositions in accordance with the invention, mention may bemade in particular of the compounds of formula (I) below, and theaddition salts thereof with an acid:

in which:

R₁ represents a hydrogen atom, a C₁-C₄ alkyl radical, a C₁-C₄monohydroxyalkyl radical, a C₂-C₄ polyhydroxyalkyl radical, a(C₁-C₄)alkoxy(C₁-C₄)alkyl radical, a C₁-C₄ alkyl radical substitutedwith a nitrogenous group, a phenyl radical or a 4′-aminophenyl radical;

R₂ represents a hydrogen atom, a C₁-C₄ alkyl radical, a C₁-C₄monohydroxyalkyl radical, a C₂-C₄ polyhydroxyalkyl radical, a(C₁-C₄)alkoxy(C₁-C₄)alkyl radical or a C₁-C₄ alkyl radical substitutedwith a nitrogenous group;

R₃ represents a hydrogen atom, a halogen atom such as a chlorine,bromine, iodine or fluorine atom, a C₁-C₄ alkyl radical, a C₁-C₄monohydroxyalkyl radical, a C₁-C₄ hydroxyalkoxy radical, anacetylamino(C₁-C₄)alkoxy radical, a C₁-C₄ mesylaminoalkoxy radical or acarbamoylamino(C₁-C₄)alkoxy radical,

R₄ represents a hydrogen or halogen atom or a C₁-C₄ alkyl radical.

Among the nitrogenous groups of formula (I) above, mention may be madein particular of amino, mono(C₁-C₄)alkylamino, di(C₁-C₄)alkylamino,tri(C₁-C₄)-alkylamino, monohydroxy(C₁-C₄)alkylamino, imidazolinium andammonium radicals.

Among the para-phenylenediamines of formula (I) above, mention may bemade more particularly of para-phenylenediamine, para-toluylenediamine,2-chloro-para-phenylenediamine, 2,3-dimethyl-para-phenylenediamine,2,6-dimethyl-para-phenylenediamine, 2,6-diethyl-para-phenylenediamine,2,5-dimethyl-para-phenylenediamine, N,N-dimethyl-para-phenylenediamine,N,N-diethyl-para-phenylenediamine, N,N-dipropyl-para-phenylenediamine,4-amino-N,N-diethyl-3-methylaniline,N,N-bis(β-hydroxyethyl)-para-phenylenediamine,4-amino-N,N-bis(β-hydroxyethyl)-2-methylaniline,4-amino-2-chloro-N,N-bis(β-hydroxyethyl)aniline,2-β-hydroxyethyl-para-phenylenediamine, 2-fluoro-para-phenylenediamine,2-isopropyl-para-phenylenediamine,N-(β-hydroxypropyl)-para-phenylenediamine,2-hydroxymethyl-para-phenylenediamine,N,N-dimethyl-3-methyl-para-phenylenediamine,N,N-(ethyl-β-hydroxyethyl)-para-phenylenediamine,N-(βγ-dihydroxypropyl)-para-phenylenediamine,N-(4′-aminophenyl)-para-phenylenediamine,N-phenyl-para-phenylenediamine,2-β-hydroxyethyloxy-para-phenylenediamine,2-β-acetylaminoethyloxy-para-phenylenediamine andN-(β-methoxyethyl)-para-phenylenediamine, and the addition salts thereofwith an acid.

Among the para-phenylenediamines of formula (I) above,para-phenylenediamine, para-toluylenediamine,2-isopropyl-para-phenylenediamine,2-β-hydroxyethyl-para-phenylenediamine,2-β-hydroxyethyloxy-para-phenylenediamine,2,6-dimethyl-para-phenylenediamine, 2,6-diethyl-para-phenylenediamine,2,3-dimethyl-para-phenylenediamine,N,N-bis(β-hydroxyethyl)-para-phenylenediamine,2-chloro-para-phenylenediamine and2-β-acetylaminoethyloxy-para-phenylenediamine and the addition saltsthereof with an acid are most particularly preferred.

According to the invention, the term double bases is understood to referto the compounds containing at least two aromatic rings bearing aminoand/or hydroxyl groups.

Among the double bases which can be used as oxidation bases in the dyecompositions in accordance with the invention, mention may be made inparticular of the compounds corresponding to formula (II) below, and theaddition salts thereof with an acid:

in which:

Z₁ and Z₂, which may be identical or different, represent a hydroxyl or—NH₂ radical which may be substituted with a C₁-C₄ alkyl radical or witha linker arm Y;

the linker arm Y represents a linear or branched alkylene chaincontaining from 1 to 14 carbon atoms, which may be interrupted by orterminated with one or more nitrogenous groups and/or one or more heteroatoms such as oxygen, sulphur or nitrogen atoms, and optionallysubstituted with one or more hydroxyl or C₁-C₄ alkoxy radicals;

R₅ and R₆ represent a hydrogen or halogen atom, a C₁-C₄ alkyl radical, aC₁-C₄ monohydroxyalkyl radical, a C₂-C₄ polyhydroxyalkyl radical, aC₁-C₄ aminoalkyl radical or a linker arm Y;

R₇, R₈, R₉, R₁₀, R₁₁ and R₁₂, which may be identical or different,represent a hydrogen atom, a linker arm Y or a C₁-C₄ alkyl radical; itbeing understood that the compounds of formula (II) contain only onelinker arm Y per molecule.

Among the nitrogenous groups of formula (II) above, mention may be madein particular of amino, mono(C₁-C₄)alkylamino, di(C₁-C₄)alkylamino,tri(C₁-C₄)alkylamino, monohydroxy(C₁-C₄)alkylamino, imidazolinium andammonium radicals.

Among the double bases of formula (II) above, mention may be made moreparticularly ofN,N′-bis(β-hydroxyethyl)-N,N′-bis(4′-aminophenyl)-1,3-diaminopropanol,N,N′-bis(β-hydroxyethyl)-N,N′-bis(4′-aminophenyl)ethylenediamine,N,N′-bis(4-aminophenyl)tetramethylenediamine,N,N′-bis(β-hydroxyethyl)-N,N′-bis(4-aminophenyl)tetramethylenediamine,N,N′-bis(4-methylaminophenyl)tetramethylenediamine,N,N′-bis-(ethyl)-N,N′-bis(4′-amino-3′-methylphenyl)ethylenediamine and1,8-bis(2,5-diaminophenoxy)-3,5-dioxaoctane, and the addition saltsthereof with an acid.

Among these double bases of formula (II),N,N′-bis(β-hydroxyethyl)-N,N′-bis(4′-aminophenyl)-1,3-diaminopropanoland 1,8-bis(2,5-diaminophenoxy)-3,5-dioxaoctane, or one of the additionsalts thereof with an acid, are particularly preferred.

Among the para-aminophenols which can be used as oxidation bases in thedye compositions in accordance with the invention, mention may be madein particular of the compounds corresponding to formula (III) below, andthe addition salts thereof with an acid:

in which:

R₁₃ represents a hydrogen or halogen atom or a C₁-C₄ alkyl, C₁-C₄monohydroxyalkyl, (C₁-C₄)alkoxy(C₁-C₄)alkyl, C₁-C₄ aminoalkyl orhydroxy(C₁-C₄)alkylamino(C_(1-C) ₄)alkyl radical,

R₁₄ represents a hydrogen or halogen atom or a C₁-C₄-alkyl, C₁-C₄monohydroxyalkyl, C₂-C₄ polyhydroxyalkyl, C₁-C₄ aminoalkyl, C₁-C₄cyanoalkyl or (C₁-C₄)alkoxy-(C₁-C₄)alkyl radical, it being understoodthat at least one of the radicals R₁₃ or R₁₄ represents a hydrogen atom.

Among the para-aminophenols of formula (III) above, mention may be mademore particularly of para-aminophenol, 4-amino-3-methylphenol,4-amino-3-fluorophenol, 4-amino-3-hydroxymethylphenol,4-amino-2-methylphenol, 4-amino-2-hydroxymethylphenol,4-amino-2-methoxymethylphenol, 4-amino-2-aminomethylphenol,4-amino-2-(β-hydroxyethylaminomethyl)phenol and 4-amino-2-fluorophenol,and the addition salts thereof with an acid.

Among the ortho-aminophenols which can be used as oxidation bases in thedye compositions in accordance with the invention, mention may be mademore particularly of 2-aminophenol, 2-amino-5-methylphenol,2-amino-6-methylphenol and 5-acetamido-2-aminophenol, and the additionsalts thereof with an acid.

Among the heterocyclic bases which can be used as oxidation bases in thedye compositions in accordance with the invention, mention may be mademore particularly of pyridine derivatives, pyrimidine derivatives,pyrazole derivatives and pyrazolopyrimidine derivatives, and theaddition salts thereof with an acid.

Among the pyridine derivatives, mention may be made more particularly ofthe compounds described, for example, in patents GB 1,026,978 and GB1,153,196, such as 2,5-diaminopyridine,2-(4-methoxyphenyl)amino-3-aminopyridine, 2,3-diamino-6-methoxypyridine,2-(β-methoxyethyl)amino-3-amino-6-methoxypyridine and3,4-diaminopyridine, and the addition salts thereof with an acid.

Among the pyrimidine derivatives, mention may be made more particularlyof the compounds described, for example, in German patent DE 2,359,399or Japanese patent JP 88-169,571 or patent application WO 96/15765, suchas 2,4,5,6-tetraaminopyrimidine, 4-hydroxy-2,5,6-triaminopyrimidine,2-hydroxy-4,5,6-triaminopyrimidine, 2,4-dihydroxy-5,6-diaminopyrimidineand 2,5,6-triaminopyrimidine, and the addition salts thereof with anacid.

Among the pyrazole derivatives, mention may be made more particularly ofthe compounds described in patents DE 3,843,892, DE 4,133,957 and patentapplications WO 94/08969, WO 94/08970, FR-A-2,733,749 and DE 195 43 988,such as 4,5-diamino-1-methylpyrazole, 3,4-diaminopyrazole,4,5-diamino-1-(4′-chlorobenzyl)pyrazole,4,5-diamino-1,3-dimethylpyrazole, 4,5-diamino-3-methyl-1-phenylpyrazole,4,5-diamino-1-methyl-3-phenylpyrazole,4-amino-1,3-dimethyl-5-hydrazinopyrazole,1-benzyl-4,5-diamino-3-methylpyrazole,4,5-diamino-3-tert-butyl-1-methylpyrazole,4,5-diamino-1-tert-butyl-3-methylpyrazole,4,5-diamino-1-(β-hydroxyethyl)-3-methylpyrazole,4,5-diamino-1-ethyl-3-methylpyrazole,4,5-diamino-1-ethyl-3-(4′-methoxyphenyl)pyrazole,4,5-diamino-1-ethyl-3-hydroxymethylpyrazole,4,5-diamino-3-hydroxymethyl-1-methylpyrazole,4,5-diamino-3-hydroxymethyl-1-isopropylpyrazole,4,5-diamino-3-methyl-1-isopropylpyrazole,4-amino-5-(2′-aminoethyl)amino-1,3-dimethylpyrazole,3,4,5-triaminopyrazole, 1-methyl-3,4,5-triaminopyrazole,3,5-diamino-1-methyl-4-methylaminopyrazole and3,5-diamino-4-(β-hydroxyethyl)amino-1-methylpyrazole, and the additionsalts thereof with an acid.

Among the pyrazolopyrimidine derivatives, mention may be made moreparticularly of the pyrazolo[1,5-a]pyrimidines of formula (IV) below,and the addition salts thereof with an acid or with a base and thetautomeric forms thereof, when a tautomeric equilibrium exists:

in which:

R₁₅, R₁₆, R₁₇ and R₁₈, which may be identical or different, denote ahydrogen atom, a C₁-C₄ alkyl radical, an aryl radial, a C₁-C₄hydroxyalkyl radical, a C₂-C₄ polyhydroxyalkyl radical, a(C₁-C₄)alkoxy(C₁-C₄)alkyl radical, a C₁-C₄ aminoalkyl radical (it beingpossible for the amine to be protected with an acetyl, ureido orsulphonyl radical), a (C₁-C₄)alkylamino(C₁-C₄)alkyl radical, adi[(C₁-C₄)alkyl]amino(C₁-C₄)alkyl radical (it being possible for thedialkyl radicals to form a 5- or 6-membered carbon-based ring or aheterocycle), a hydroxy(C₁-C₄)alkyl- ordi[hydroxy-(C₁-C₄)alkyl]amino(C₁-C₄)alkyl radical;

the radicals X, which may be identical or different, denote a hydrogenatom, a C₁-C₄ alkyl radical, an aryl radical, a C₁-C₄ hydroxyalkylradical, a C₂-C₄ polyhydroxyalkyl radical, a C₁-C₄ aminoalkyl radical, a(C₁-C₄)alkylamino(C₁-C₄)alkyl radical, adi[(C₁-C₄)alkyl]amino(C₁-C₄)alkyl radical (it being possible for thedialkyls to form a 5- or 6-membered carbon-based ring or a heterocycle),a hydroxy(C₁-C₄)alkyl- or di-[hydroxy(C₁-C₄)alkyl]amino(C₁-C₄)alkylradical, an amino radical, a (C₁-C₄)alkyl- or di[(C₁-C₄)alkyl]aminoradical; a halogen atom, a carboxylic acid group or a sulphonic acidgroup;

i is equal to 0, 1, 2 or 3;

p is equal to 0 or 1;

q is equal to 0 or 1;

n is equal to 0 or 1;

with the proviso that:

the sum p+q is other than 0;

when p+q is equal to 2, then n is equal to 0 and the groups NR₁₅R₁₆ andNR₁₇R₁₈ occupy the (2,3); (5,6); (6,7); (3,5) or (3,7) positions;

when p+q is equal to 1, then n is equal to 1 and the group NR₁₅R₁₆ (orNR₁₇R₁₈) and the OH group occupy the (2,3); (5,6); (6,7); (3,5) or (3,7)positions.

When the pyrazolo[1,5-a]pyrimidines of formula (IV) above are such thatthey contain a hydroxyl group on one of the positions 2, 5 or 7 α to anitrogen atom, a tautomeric equilibrium exists represented, for example,by the following scheme:

Among the pyrazolo[1,5-a]pyrimidines of formula (IV) above, mention maybe made in particular of:

pyrazolo[1,5-a]pyrimidine-3,7-diamine;

2,5-dimethylpyrazolo[1,5-a]pyrimidine-3,7-diamine;

pyrazolo[1,5-a]pyrimidine-3,5-diamine;

2,7-dimethylpyrazolo[1,5-a]pyrimidine-3,5-diamine;

3-aminopyrazolo[1,5-a]pyrimidin-7-ol;

3-aminopyrazolo[1,5-a]pyrimidin-5-ol;

2-(3-aminopyrazolo[1,5-a]pyrimidin-7-ylamino)ethanol;

2-(7-aminopyrazolo[1,5-a]pyrimidin-3-ylamino)ethanol;

2-[(3-aminopyrazolo[1,5-a]pyrimidin-7-yl)-(2-hydroxyethyl)amino]ethanol;

2-[(7-aminopyrazolo[1,5-a]pyrimidin-3-yl)-(2-hydroxyethyl)amino]ethanol;

5,6-dimethylpyrazolo[1,5-a]pyrimidine-3,7-diamine;

2,6-dimethylpyrazolo[1,5-a]pyrimidine-3,7-diamine;

2,5,N7,N7-tetramethylpyrazolo[1,5-a]pyrimidine-3,7-diamine; and theaddition salts thereof and the tautomeric forms thereof, when atautomeric equilibrium exists.

The pyrazolo[1,5-a]pyrimidines of formula (IV) above can be prepared bycyclization starting with an aminopyrazole, according to the synthesesdescribed in the following references:

EP 628559 Beiersdorf-Lilly.

R. Vishdu, H. Navedul, Indian J. Chem., 34b (6), 514, 1995.

N. S. Ibrahim, K. U. Sadek, F. A. Abdel-Al, Arch. Pharm., 320, 240,1987.

R. H. Springer, M. B. Scholten, D. E. O'Brien, T. Novinson, J. P.Miller, R. K. Robins, J. Med. Chem., 25, 235, 1982.

T. Novinson, R. K. Robins, T. R. Matthews, J. Med. Chem., 20, 296, 1977.

U.S. Pat. No. 3,907,799 ICN Pharmaceuticals.

The pyrazolo[1,5-a]pyrimidines of formula (IV) above can also beprepared by cyclization starting from hydrazine, according to thesyntheses described in the following references:

A. McKillop and R. J. Kobilecki, Heterocycles, 6(9), 1355, 1977.

E. Alcade, J. De Mendoza, J. M. Marcia-Marquina, C. Almera, J. Elguero,J. Heterocyclic Chem., 11(3), 423, 1974.

K. Saito, I. Hori, M. Higarashi, H. Midorikawa, Bull. Chem. Soc. Japan,47(2), 476, 1974.

The oxidation base(s) in accordance with the invention preferablyrepresent(s) from 0.0005 to 12% by weight approximately relative to thetotal weight of the ready-to-use dye composition, and even morepreferably from 0.005 to 6% by weight approximately relative to thisweight.

The couplers which can be used are those used conventionally inoxidation dye compositions, i.e. meta-phenylenediamines,meta-aminophenols and meta-diphenols, mono- or polyhydroxylatednaphthalene derivatives, sesamol and its derivatives and heterocycliccompounds such as, for example, indole derivatives, indolinederivatives, benzimidazole derivatives, benzomorpholine derivatives,sesamol derivatives, pyrazoloazole derivatives, pyrroloazolederivatives, imidazoloazole derivatives, pyrazolopyrimidine derivatives,pyrazoline-3,5-dione derivatives, pyrrolo[3,2-d]oxazole derivatives,pyrazolo[3,4-d]thiazole derivatives, thiazoloazole S-oxide derivativesand thiazoloazole S,S-dioxide derivatives, and the addition saltsthereof with an acid.

These couplers can be chosen in particular from 2-methyl-5-aminophenol,5-N-(β-hydroxyethyl)amino-2-methylphenol, 3-aminophenol,1,3-dihydroxybenzene, 1,3-dihydroxy-2-methylbenzene,4-chloro-1,3-dihydroxybenzene, 2,4-diamino-1-(β-hydroxyethyloxy)benzene,2-amino-4-(β-hydroxyethylamino)-1-methoxybenzene, 1,3-diaminobenzene,1,3-bis(2,4-diaminophenoxy)propane, sesamol, α-naphthol,6-hydroxyindole, 4-hydroxyindole, 4-hydroxy-N-methylindole,6-hydroxyindoline, 2,6-dihydroxy-4-methylpyridine,1H-3-methylpyrazol-5-one and 1-phenyl-3-methylpyrazol-5-one, and theaddition salts thereof with an acid.

When they are present, these couplers preferably represent from 0.0001to 10% by weight approximately relative to the total weight of theready-to-use dye composition, and even more preferably from 0.005 to 5%by weight approximately relative to this weight.

In general, the addition salts with an acid which can be used in thecontext of the dye compositions of the invention (oxidation bases andcouplers) are chosen in particular from the hydrochlorides,hydrobromides, sulphates, tartrates, lactates and acetates.

The dye composition of the invention can also contain, in addition tothe oxidation bases defined above and the optional combined couplers,direct dyes to enrich the shades with glints. These direct dyes can bechosen in particular from nitro dyes, azo dyes or anthraquinone dyes.

The subject of the invention is also a process for dyeing keratinfibres, and in particular human keratin fibres such as the hair, usingthe ready-to-use dye composition as defined above.

According to this process, at least one ready-to-use dye composition asdefined above is placed on the fibres, for a period which is sufficientto develop the desired coloration, after which the fibres are rinsed,optionally washed with shampoo, rinsed again and dried.

The time required to develop the coloration on the keratin fibres isgenerally between 3 and 60 minutes and even more precisely between 5 and40 minutes.

According to a first specific embodiment of the invention, the processincludes a first step which consists in separately storing, on the onehand, a composition (A) comprising, in a medium which is suitable fordyeing, at least one oxidation base and optionally at least one coupleras defined above, and, on the other hand, a composition (B) containing,in a medium which is suitable for dyeing, at least one enzyme of2-electron oxidoreductase type in the presence of at least one donor forthe said enzyme and at least one nonionic guar gum containing at leastone hydrophilic unit and at least one fatty chain, and then in mixingthem together at the time of use, before applying this mixture to thekeratin fibres.

According to another specific embodiment of the invention, the nonionicguar gum is incorporated into composition (A).

Another subject of the invention is a multi-compartment dyeing device or“kit” or any other multi-compartment packaging system, a firstcompartment of which contains composition (A) as defined above and asecond compartment of which contains composition (B) as defined above.These devices can be equipped with means for applying the desiredmixture to the hair, such as the devices described in patentFR-2,586,913 in the name of the Applicant.

A subject of the present invention is also a novel process for treatingkeratin substances, in particular the hair, in order to obtain apermanent reshaping of this hair, in particular in the form ofpermanent-waved hair, this process comprising the following steps: (i) areducing composition is applied to the keratin substance to be treated,the keratin substance being placed under mechanical tension before,during or after the said application, (ii) the keratin substance isoptionally rinsed, (iii) an oxidizing composition as defined above isapplied to the optionally rinsed keratin substance, (iv) the keratinsubstance is optionally rinsed again.

The first step (i) of this process consists in applying a reducingcomposition to the hair. This application is carried out lock by lock orall at once.

The reducing composition comprises, for example, at least one reducingagent, which can be chosen in particular from thioglycolic acid,cysteine, cysteamine, glyceryl thioglycolate, thiolactic acid orthiolactic or thioglycolic acid salts.

The usual step for placing the hair under tension in a shapecorresponding to the desired final shape for this hair (for examplecurls) can be carried out by any suitable means, in particularmechanical means, known per se for maintaining the hair under tension,such as, for example, rollers, curlers and the like.

The hair can also be shaped without the aid of external means, simplywith the fingers.

Before carrying out the following optional rinsing step (ii), the haironto which the reducing composition has been applied should,conventionally, be left to stand for a few minutes, generally between 5minutes and one hour, preferably between 10 and 30 minutes, so as togive the reducing agent enough time to act correctly on the hair. Thiswaiting phase preferably takes place at a temperature ranging from 35°C. to 45° C., while preferably also protecting the hair with a hood.

In the optional second step of the process (step (ii)), the hairimpregnated with the reducing composition is then rinsed thoroughly withan aqueous composition.

Next, in a third step (step (iii)), the oxidizing composition of theinvention is applied to the hair thus rinsed, with the aim of fixing thenew shape given to the hair.

As in the case of the application of the reducing composition, the haironto which the oxidizing composition has been applied is then,conventionally, left for a standing or waiting phase lasting a fewminutes, generally between 3 and 30 minutes, preferably between 5 and 15minutes.

If the hair was maintained under tension by external means, these means(rollers, curlers or the like) can be removed from the hair before orafter the fixing step.

Lastly, in the final step of the process according to the invention(step (iv)), which is also optional, the hair impregnated with theoxidizing composition is rinsed thoroughly, generally with water.

Hair which is soft and easy to disentangle is finally obtained. The hairis wavy.

The oxidizing composition according to the invention can also be used ina process for bleaching keratin fibres, and in particular the hair.

The bleaching process according to the invention comprises a step ofapplying an oxidizing composition according to the invention to thekeratin fibres in the presence or absence of an auxiliary oxidizingagent. Conventionally, a second step of the bleaching process accordingto the invention is a step of rinsing the keratin fibres.

The medium which is suitable for the keratin fibres (or the support) forthe ready-to-use dye compositions and for the oxidation compositionsused for the permanent reshaping or bleaching of keratin fibres inaccordance with the invention generally consists of water or of amixture of water and at least one organic solvent in order to dissolvethe compounds which would not be sufficiently soluble in water. By wayof organic solvent, mention may be made, for example, of C₁-C₄ alkanolssuch as ethanol and isopropanol; glycerol; glycols and glycol etherssuch as 2-butoxyethanol, propylene glycol, propylene glycol monomethylether, diethylene glycol monoethyl ether and monomethyl ether, andaromatic alcohols such as benzyl alcohol or phenoxyethanol, similarproducts and mixtures thereof.

The solvents can be present in proportions preferably of between 1 and40% by weight approximately relative to the total weight of the dyecomposition, and even more preferably between 5 and 30% by weightapproximately.

The pH of the ready-to-use dye compositions and of the oxidizingcompositions used for the permanent reshaping or bleaching of thekeratin fibres in accordance with the invention is chosen such that theenzymatic activity of the 2-electron oxidoreductase is not adverselyaffected. It is generally between 5 and 11 approximately, and preferablybetween 6.5 and 10 approximately. It can be adjusted to the desiredvalue using acidifying or basifying agents usually used for dyeingkeratin fibres.

Among the acidifying agents, mention may be made, by way of example, ofinorganic or organic acids such as hydrochloric acid, orthophosphoricacid, sulphuric acid, carboxylic acids such as acetic acid, tartaricacid, citric acid or lactic acid, and sulphonic acids.

Among the basifying agents, mention may be made, by way of example, ofaqueous ammonia, alkaline carbonates, alkanolamines such as mono-, di-and triethanolamines, 2-methyl-2-aminopropanol and derivatives thereof,sodium hydroxide, potassium hydroxide and the compounds of formula (V)below:

in which W is a propylene residue optionally substituted with a hydroxylgroup or a C₁-C₄ alkyl radical; R₁₃, R₁₄, R₁₅ and R₁₆, which may beidentical or different, represent a hydrogen atom or a C₁-C₄ alkyl orC₁-C₄ hydroxyalkyl radical.

The ready-to-use dye compositions and the oxidizing compositions for thepermanent reshaping or bleaching of keratin fibres in accordance withthe invention can also contain various adjuvants used conventionally incompositions for dyeing, permanently reshaping or bleaching the hair,such as anionic, cationic, nonionic, amphoteric or zwitterionicsurfactants or mixtures thereof, anionic, cationic, nonionic, amphotericor zwitterionic polymers or mixtures thereof, inorganic or organicthickeners, antioxidants, enzymes other than the 2-electronoxidoreductases used in accordance with the invention, such as, forexample, peroxidases, penetration agents, sequestering agents,fragrances, buffers, dispersing agents, conditioners such as, forexample, silicones, film-forming agents, preserving agents andopacifiers.

Needless to say, a person skilled in the art will take care to selectthis or these optional complementary compound(s) such that theadvantageous properties intrinsically associated with the compositionsin accordance with the invention are not, or are not substantially,adversely affected by the addition or additions envisaged.

The ready-to-use dye compositions and the oxidizing compositions usedfor the permanent reshaping or bleaching of keratin fibres in accordancewith the invention can be in various forms, such as in the form ofliquids, creams or gels, which are optionally pressurized, or in anyother form which is suitable for dyeing, permanently reshaping orbleaching keratin fibres, and in particular human hair.

In the case of a ready-to-use dye composition, the oxidation dyes(s) andthe 2-electron oxido-reductase(s) are present in the said composition,which must be free of oxygen gas, so as to avoid any premature oxidationof the oxidation dye(s).

Concrete examples illustrating the invention will now be given.

In the text hereinabove and hereinbelow, except where otherwisementioned, the percentages are expressed on a weight basis.

The examples which follow illustrate the invention without beinglimiting in nature.

EXAMPLE 1

Dye Composition

The ready-to-use dye composition below was prepared (contents in grams):

Uricase from Arthrobacter globiformis at a concentration of 20International Units (I.U.)/mg, sold by the company Sigma 1.5 g

Uric acid 1.5 g

(C₈-C₁₀)alkyl polyglucoside as an aqueous solution containing 60% activematerial (A.M.), sold under the name Oramix CG110 by the company SEPPIC8.0 g

Para-phenylenediamine 0.324 g

Resorcinol 0.32 g

Hydroxypropyl guar gum sold under the name Jaguar HP 60 by the companyMayhall 1.6 g

Ethanol 20.0 g

Monoethanolamine qs pH 9.5

Demineralized water qs 100 g

This ready-to-use dye composition was applied to locks of natural greyhair containing 90% white hairs for 30 minutes. The hair was thenrinsed, washed with a standard shampoo and then dried.

Locks of hair dyed a matt dark-blond colour were obtained.

EXAMPLE 2

Oxidizing Composition for Permanent-waving or Bleaching

Uricase from Arthrobacter globiformis at a concentration of 20International Units (I.U.)/mg, sold by the company Sigma 1.8 g

Uric acid 1.65 g

Ethanol 20.0 g

(C₈-C₁₀)alkyl polyglucoside as an aqueous solution containing 60% activematerial (A.M.), sold under the name Oramix CG110 by the company SEPPIC8.0 g

Hydroxypropyl guar gum sold under the name Jaguar HP 60 by the companyMayhall 0.25 g

2-Methyl-2-amino-1-propanol qs pH 9.5

Demineralized water qs 100 g

What is claimed is:
 1. A cosmetic or dermatological composition fortreating keratin fibers comprising: at least one enzyme chosen from2-electron oxidoreductases; at least one donor for said at least oneenzyme; and at least one nonionic guar gum.
 2. The composition of claim1, wherein said 2-electron oxidoreductases are chosen from pyranoseoxidases, glucose oxidases, glycerol oxidases, lactate oxidases,pyruvate oxidases and uricases.
 3. The composition of claim 2, whereinsaid 2-electron oxidoreductases are chosen from uricases of animal,microbiological and biotechnological origin.
 4. The composition of claim1, wherein said at least one enzyme is present in an amount ranging from0.01% to 20% by weight relative to the total weight of the composition.5. The composition of claim 4, wherein said at least one enzyme ispresent in an amount ranging from 0.1% to 5% by weight relative to thetotal weight of the composition.
 6. The composition of claim 1, whereinsaid at least one donor is chosen from D-glucose, L-sorbose, D-xylose,glycerol, dihydroxyacetone, lactic acid and its salts, pyruvic acid andits salts, and uric acid and its salts.
 7. The composition of claim 6,wherein said at least one donor is chosen from uric acid and its salts.8. The composition of claim 1, wherein said at least one donor ispresent in an amount ranging from 0.01% to 20% by weight relative to thetotal weight of the composition.
 9. The composition of claim 8, whereinsaid at least one donor is present in an amount ranging from 0.1% to 5%by weight relative to the total weight of the composition.
 10. Thecomposition of claim 1, wherein said at least one nonionic guar gum ischosen from unmodified guar gums and chemically modified guar gums. 11.The composition of claim 10, wherein said chemically modified guar gumsare modified with C₁-C₆ hydroxyalkyl groups.
 12. The composition ofclaim 11, wherein said C₁-C₆ hydroxyalkyl groups are chosen fromhydroxymethyl, hydroxyethyl, hydroxypropyl and hydroxybutyl groups. 13.The composition of claim 11, wherein said chemically modified guar gumsmodified with C₁-C₆ hydroxyalkyl groups have a degree ofhydroxyalkylation ranging from 0.4 to 1.2.
 14. The composition of claim12, wherein said chemically modified guar gums modified with said C₁-C₆hydroxyalkyl groups have a degree of hydroxyalkylation ranging from 0.4to 1.2.
 15. The composition of claim 1, wherein said at least onenonionic guar gum is present in an amount ranging from 0.01% to 10% byweight relative to the total weight of the composition.
 16. Thecomposition of claim 15, wherein said at least one nonionic guar gum ispresent in an amount ranging from 0.1% to 5% by weight relative to thetotal weight of the composition.
 17. The composition of claim 1, furthercomprising at least one oxidation base.
 18. The composition of claim 17,wherein said at least one oxidation base is chosen frompara-phenylenediamines, double bases, ortho- and para-aminophenols,heterocyclic bases, and acid addition salts thereof.
 19. The compositionof claim 18, wherein said at least one oxidation base is chosen from:para-phenylenediamine compounds chosen from: para-phenylenediamine,para-toluylenediamine, 2-chloro-para-phenylenediamine,2,3-dimethyl-para-phenylenediamine, 2,6-dimethyl-para-phenylenediamine,2,6-diethyl-para-phenylenediamine, 2,5-dimethyl-para-phenylenediamine,N,N-dimethyl-para-phenylenediamine, N,N-diethyl-para-phenylenediamine,N,N-dipropyl-para-phenylenediamine, 4-amino-N,N-diethyl-3-methylaniline,N,N-bis(β-hydroxyethyl)-para-phenylenediamine,4-amino-N,N-bis(β-hydroxyethyl)-2-methylaniline,4-amino-2-chloro-N,N-bis(β-hydroxyethyl)aniline,2-β-hydroxyethyl-para-phenylenediamine, 2-fluoro-para-phenylenediamine,2-isopropyl-para-phenylenediamine,N-(β-hydroxypropyl)-para-phenylenediamine,2-hydroxymethyl-para-phenylenediamine,N,N-dimethyl-3-methyl-para-phenylenediamine,N,N-(ethyl-β-hydroxyethyl)-para-phenylenediamine,N-(β,γ-dihydroxypropyl)-para-phenylenediamine,N-(4′-aminophenyl)-para-phenylenediamine,N-phenyl-para-phenylenediamine,2-β-hydroxyethyloxy-para-phenylenediamine,2-β-acetylaminoethyloxy-para-phenylenediamine,N-(β-methoxyethyl)-para-phenylenediamine, and acid-addition saltsthereof; double bases chosen from:N,N′-bis(β-hydroxyethyl)-N,N′-bis(4′-aminophenyl)-1,3-diaminopropanol,N,N′-bis(β-hydroxyethyl)-N,N′-bis(β′-aminophenyl)ethylenediamine,N,N′-bis(4-aminophenyl)tetramethylenediamine,N,N′-bis(β-hydroxyethyl)-N,N′-bis(4-aminophenyl)tetramethylenediamine,N,N′-bis(4-methylaminophenyl)tetramethylenediamine,N,N′-bis(ethyl)-N,N′-bis(4′-amino-3′-methylphenyl)ethylenediamine,1,8-bis(2,5-diaminophenoxy)-3,5-dioxaoctane, and acid-addition saltsthereof; ortho-aminophenols chosen from: 2-aminophenol,2-amino-5-methylphenol, 2-amino-6-methylphenol,5-acetamido-2-aminophenol, and acid-addition salts thereof; pyridinecompounds chosen from: 2,5-diaminopyridine,2-(4-methoxyphenyl)amino-3-amino-pyridine,2,3-diamino-6-methoxypyridine,2-(ÿ-methoxy-ethyl)amino-3-amino-6-methoxypyridine, 3,4-diaminopyridine,and acid-addition salts thereof; pyrimidine compounds chosen from:2,4,5,6-tetraamino-pyrimidine, 4-hydroxy-2,5,6-triaminopyrimidine,2-hydroxy-4,5,6-triamino-pyrimidine,2,4-dihydroxy-5,6-diaminopyrimidine, 2,5,6-tri-amino-pyrimidine, andacid-addition salts thereof; pyrazole compounds chosen from:4,5-diamino-1-methyl-pyrazole, 3,4-diaminopyrazole,4,5-diamino-1-(4′-chlorobenzyl)pyrazole,4,5-diamino-1,3-dimethyl-pyrazole,4,5-diamino-3-methyl-1-phenylpyrazole,4,5-diamino-1-methyl-3-phenylpyrazole,4-amino-1,3-di-methyl-5-hydrazinopyrazole,1-benzyl-4,5-diamino-3-methyl-pyrazole,4,5-diamino-3-tert-butyl-1-methyl-pyrazole,4,5-diamino-1-tert-butyl-3-methylpyrazole,4,5-diamino-1-(β-hydroxyethyl)-3-methylpyrazole,4,5-diamino-1-ethyl-3-methylpyrazole,4,5-diamino-1-ethyl-3-(4′-methoxyphenyl)pyrazole,4,5-diamino-1-ethyl-3-hydroxymethylpyrazole,4,5-diamino-3-hydroxymethyl-1-methyl-pyrazole,4,5-diamino-3-hydroxymethyl-1-iso-propyl-pyrazole,4,5-diamino-3-methyl-1-isopropyl-pyrazole,4-amino-5-(2′-amino-ethyl)amino-1,3-dimethyl-pyrazole,3,4,5-triamino-pyrazole, 1-methyl-3,4,5-tri-amino-pyrazole,3,5-diamino-1-methyl4-methylamino-pyrazole,3,5-diamino4-(β-hydroxyethyl)amino-1-methyl-pyrazole, and acid-additionsalts thereof, and pyrazolopyrimidine compounds chosen from:pyrazolo[1,5-a]pyrimidine-3,7-diamine,2,5-dimethylpyrazolo[1,5-a]pyrimidine-3,7-diamine,pyrazolo[1,5-a]pyrimidine-3,5-diamine,2,7-dimethylpyrazolo[1,5-a]pyrimidine-3,5-diamine,3-aminopyrazolo[1,5-a]pyrimidin-7-ol,3-aminopyrazolo[1,5-a]pyrimidin-5-ol,2-(3-aminopyrazolo[1,5-a]pyrimidin-7-ylamino)ethanol,2-(7-aminopyrazolo[1,5-a]pyrimidin-3-ylamino)ethanol,2-[(3-aminopyrazolo[1,5-a]pyrimidin-7-yl)-(2-hydroxy-ethyl)amino]ethanol,2-[(7-aminopyrazolo[1,5-a]pyrimidin-3-yl)-(2-hydroxy-ethyl)amino]ethanol,5,6-dimethylpyrazolo[1,5-a]pyrimidine-3,7-diamine,2,6-dimethylpyrazolo[1,5-a]pyrimidine-3,7-diamine,2,5,N7,N7-tetramethylpyrazolo[1,5-a]pyrimidine-3,7-diamine; and additionsalts thereof and the tautomeric forms thereof, when a tautomericequilibrium exists.
 20. The composition of claim 1, further comprisingat least one coupler.
 21. The composition of claim 20, wherein said atleast one coupler is a meta-aminophenol coupler chosen frommeta-aminophenol, 5-amino-2-methoxyphenol,5-amino-2-(β-hydroxyethyloxy)phenol, 5-amino-2-methylphenol,5-N-(β-hydroxyethyl)amino-2-methylphenol,5-N-(β-hydroxyethyl)amino-4-methoxy-2-methylphenol,5-amino-4-methoxy-2-methylphenol, 5-amino-4-chloro-2-methylphenol,5-amino-2,4-dimethoxyphenol, 5-(γ-hydroxypropylamino)-2-methylphenol andacid-addition salts thereof.
 22. The composition of claim 1, furthercomprising water or a mixture of water and at least one organic solvent.23. The composition of claim 22, wherein said at least one organicsolvent is present in an amount ranging from 1% to 40% by weightrelative to the total weight of the composition.
 24. The composition ofclaim 23, wherein said at least one organic solvent is present an amountranging from 5% to 30% by weight relative to the total weight of thecomposition.
 25. The composition of claim 1, said composition having apH ranging from 5to
 11. 26. The composition of claim 25, wherein said pHranges from 6.5 to
 10. 27. The composition of claim 1, furthercomprising at least one adjuvant chosen from anionic, cationic,nonionic, amphoteric and zwifterionic surfactants; anionic, cationic,nonionic, amphoteric and zwitterionic polymers; inorganic and organicthickeners, antioxidants, enzymes other than said at least one enzymechosen from 2-electron oxidoreductases, penetration agents, sequesteringagents, fragrances, buffers, dispersing agents, conditioners,film-forming agents, preserving agents and opacifiers.
 28. Thecomposition of claim 1, wherein said composition comprises: at least one2-electron oxidoreductase enzyme chosen from pyranose oxidases, glucoseoxidases, glycerol oxidases, lactate oxidases, pyruvate oxidases anduricases; at least one donor for said at least one enzyme chosen fromD-glucose, L-sorbose, D-xylose, glycerol, dihydroxyacetone, pyruvic acidand its salts, lactic acid and its salts, and uric acid and its salts;and at least one nonionic guar gum chosen from unmodified guar gums andchemically modified guar gums, wherein said chemically modified guargums are modified with C₁-C₆ hydroxyalkyl groups chosen fromhydroxymethyl, hydroxyethyl, hydroxypropyl and hydroxybutyl groups,wherein said C₁-C₆ hydroxyalkyl groups have a degree ofhydroxyalkylation ranging from 0.4 to 1.2.